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•Only 30% of patients fully respond to the initial SSRI •Ultimately less than 55% of people respond to any SSRI. • WHY??? • SSRIs typically only work on the 5HTIA receptor, but multiple 5HT receptors are involved in mood regulation: 1, 2, • SSRIs only impact one area of possible dysfunction • Serotonin creation, secretion, absorption, distribution is impacted by multiple factors. Learn more about your ad choices. Visit megaphone.fm/adchoices